Ryan Weaver (Ray Liotta) is a serial killer and Teri Halloran (Lauren Holly) is a female flight attendant. As they begin their ascent, the flight crew is warned of severe weather ahead. Even as they experience the first tremors of turbulence, far more dangerous storm clouds begin to gether inside the jumbo jet. Both are left to battle for control of the plane. The FBI, feeling the situation is hopeless, gives her coordinates so that even if she does get control of the plane to land it, the coordinates will send her out to sea so that she will crash into the sea and not at the airport...or will she?